First rule out the dangerous causes: perforation, obstruction, bowel ischaemia, ruptured AAA, ectopic pregnancy, sepsis.
Older people and patients on steroids or opioids can look well despite serious disease.
Act now
- 1
Give analgesia — do not withhold it while waiting for the surgical review.
- 2
Nil by mouth if surgical cause possible; IV access and fluids; antiemetic; NG tube if obstructed and vomiting.
Assess
- Onset, site, character, radiation; vomiting; bowels and flatus; urine output; post-op day.
- Examine for peritonism, distension, hernias, pulsatile mass, catheter or palpable bladder.
- Medical causes: inferior MI, DKA, lower-lobe pneumonia, pancreatitis, urinary retention, constipation.
- Drug chart: opioids, anticoagulants, NSAIDs.
Investigations
- FBC, U&E, LFT, amylase or lipase, CRP, venous gas with lactate, glucose (ketones if diabetic), group and save.
- Urine dip and pregnancy test in anyone who could be pregnant; ECG.
- Erect CXR for free air; CT as advised by the senior or surgeons.
Manage
- Suspected sepsis: follow the sepsis pathway.
- Urinary retention: bladder scan and catheter. Constipation: laxatives, review opioids.
- Pain out of proportion to examination, especially with AF: think bowel ischaemia.
Escalate when
- Peritonism, rising lactate, suspected AAA, ischaemia, obstruction or perforation: senior and surgeons now. Positive pregnancy test with pain: gynaecology.
Doses and prescribing
Paracetamol
1 g oral or IV every 6 hours (max 4 g/day; 15 mg/kg if under 50 kg).
Morphine
1–2 mg IV increments titrated to effect (opioid-naive), with an antiemetic.
Cyclizine
50 mg IV, IM or oral up to 3 times daily.
Check the BNF and your local formulary before prescribing.
Written to current guidance (NICE NG253, NG185) · sources checked 14 Nov 2026. We watch NICE for updates weekly.
Sources (3)
- NICE NG253 — Suspected sepsis in people aged 16 or overVersion 23 Sept 2026, checked 14 Nov 2026
- NICE NG185 — Acute coronary syndromesVersion 18 Nov 2020, checked 14 Nov 2026
- BNF — check doses, cautions and renal adjustmentchecked 14 Nov 2026
Reviewed by Aboodee Alhasso, MPharm MRCPharm IP on 14 Nov 2026
For healthcare professionals, as an aid to clinical judgement — not a substitute for it. Follow your local policy and ask a senior when in doubt.