A rising respiratory rate is often the earliest sign of deterioration — count it over a full minute.
Anxiety is a diagnosis of exclusion.
Act now
- 1
Sit up; oxygen to target (94–98%, or 88–92% if at risk of hypercapnia).
- 2
Calculate NEWS2. Suspected sepsis: follow the sepsis pathway.
Assess
- ABCDE: SpO₂, work of breathing, chest sounds, heart rate, BP, temperature, GCS.
- Lungs: pneumonia, asthma or COPD, pleural effusion, pneumothorax.
- Heart and vessels: pulmonary oedema, PE, arrhythmia.
- Metabolic acidosis (deep, sighing breaths): sepsis, DKA, AKI, salicylate or toxic alcohol.
- Pain, fever, anaemia.
Investigations
- Blood gas: pH, CO₂, lactate, glucose; ketones if diabetic.
- CXR, ECG, FBC, U&E, CRP; Wells score and D-dimer or CTPA if PE is possible.
Manage
- Treat the cause: antibiotics for pneumonia, diuretic for pulmonary oedema, bronchodilators for asthma or COPD, anticoagulation for PE, analgesia for pain.
- Reassess the respiratory rate after each intervention.
Escalate when
- RR 25 or more, rising oxygen need, a rising CO₂ or acidosis, or the patient tiring: senior, outreach and critical care.
Written to current guidance (NICE NG253, NG158, NG250) · sources checked 14 Nov 2026. We watch NICE for updates weekly.
Sources (5)
- Royal College of Physicians — National Early Warning Score (NEWS) 2Version 19 Dec 2017, checked 14 Nov 2026
- BTS guideline for oxygen use in adults in healthcare and emergency settings (2017)Version 1 May 2017, checked 14 Nov 2026
- NICE NG253 — Suspected sepsis in people aged 16 or overVersion 23 Sept 2026, checked 14 Nov 2026
- NICE NG158 — Venous thromboembolic diseasesVersion 2 Aug 2023, checked 14 Nov 2026
- NICE NG250 — Pneumonia: diagnosis and managementVersion 2 Sept 2025, checked 14 Nov 2026
Reviewed by Aboodee Alhasso, MPharm MRCPharm IP on 14 Nov 2026
Calculators for this
For healthcare professionals, as an aid to clinical judgement — not a substitute for it. Follow your local policy and ask a senior when in doubt.